CSO: Dr. Yair Fisher
GliXogen Therapeutics is a biopharmaceutical company developing a treatment to enhance remyelination in neurodegenerative disorders which are driven by damage to the neuron’s myelin sheath, such as multiple sclerosis (MS). All approved drugs to date treat MS patients by targeting the immune system and modulating it via various types of mechanisms while unable to address the neurological damage already present at the time of initial diagnosis. Demyelination accounts, at least in part, for the progression of 75% of relapsing-remitting MS patients towards the secondary progressive, more severe form of the disease.
GliXogen Therapeutics has discovered selective small molecule inhibitors of the transcription factor Gli1, a novel target that facilitates neuronal remyelination towards modifying the outcome of the disease.
Gli1 is a transcription factor belonging to the Hedgehog signaling pathway. It was shown that neural stem cells (NSC) that express Gli1 give rise to progeny cells which migrate to sites of demyelination where they differentiate into functional, mature oligodendrocytes which remyelinate nerve axons. Inhibition of Gli1 was shown to enhance this phenomenon and improve the clinical signs and remyelination in several in vivo models. GliXogen Therapeutics technology is unique as it one of the few pharmaceutical companies with the technology targeting NSC to replenish the pool of myelin-producing oligodendrocytes, which we believe may overcome many of the challenges of generating sustainable remyelination in the CNS.
Yair Fisher, PhD – CSO
Dr. Fisher earned his PhD from the Ben-Gurion University of the Negev in the field of neuroimmunology. He headed two pre-clinical projects at BioLineRx, a clinical stage biopharmaceutical company focused on oncology, as a project director. Previously, held various positions at the QC & R&D department at CureTech, a clinical stage immune-oncology company.
James Salzer, MD, PhD – Inventor
James Salzer is a Professor of Neuroscience, Physiology and Neurology at the NYU School of Medicine. Prof. Salzer has published over 90 papers in peer-reviewed journals and is recognized as an expert in the field of myelin signaling as well as axon-glial interactions.